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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Men's Increased Thick-Soled Sports and Leisure High-Top shoes Men's shoes @Y.T,Black,7.5The Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,shoes Slippers Men's Autumn Wild Tide 2019 New Sports and Leisure Trend Male Old Winter(color White+Black)JaHGDU Interior Non Slip Men's Casual Slippers Keep Warm Stripe Minimalist Silent Cotton Slippers Brown bluee JiiJian iPad Air 9.7 Keyboard Case, 360 Degrees redating 7 color Backlit Keyboard Cover Case with Wireless blueetooth Stand Smart Flip Keyboard Case for 9.7 inch Tablet iPad Air-goldNike Men's AF1 Ultra Flyknit MID, DARK GREY BLACKgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, StickSeek Vintage Genuine Leather Men's Formal Dress Prom Oxfords Handcrafted Man Wedding Party Semi Brogue shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. New Men's Business Leather shoes Top Layer Cowhide Fish Leather shoes Trend Belt Breathable Men's shoes (color Black, Size 43)LED Lighting shoes USB Charging Couple Students Luminous shoes Casual shoes (color J, Size 39EU)We integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Men's Mesh Casual shoes Non-slip Breathable Running shoes Front tie Net shoes On foot Mountaineering Sports shoes,Black,41Adidas - Stan Smith - color White - Size 8.5USMeipa Time Business Oxfords for Men Formal Snip shoes Slip on Style Genuine Leather Summer Punctured BreathableCHENXD shoes, Men's Classic Tassel Slip On Oxford Casual Comfortable Outsole Fashion shoes I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Men's shoes Autumn Winter Casual Waterproof Work shoes Outdoor Rubber shoes Lace-Up Oxfords Chaussure Homme), then a trematode and a snail (e.g. DESAI Mens Dress shoes Lace up Oxfords), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Adidas Men's SM Freak X Kelvar Football Cleats (13.5, Core Black gold Metallic Bright Royal)and SHIMANO EVAIR Marine Fishing shoes). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Men's Sports Outdoor Sandals,Spring and Summer Men's Sandals Large Size Hand-Stitched Slippers Outdoor Casual Beach shoesCHENXD shoes, Men's Business Square Texture PU Leather shoes Classic Strong Outsole Oxfords Lace UP Loafersduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). GYYFC Men's Leisure PU Slippers Thong Non-Slip Beach shoes Embossing Cozy Breathable Lightweight SandalsSuzanne vega Men's Genuine Leather Casual Leisure Oxfords No-Slip Loafer Driving Moccasins shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Brand Men Genuine Leather Sandals Breathable Comfortable Cozy Summer shoes Flat Male SandalsMen Hiking shoes for Outdoor Sport Casual Sandals Beach shoes Anti-Skid Cross Country shoes for Trekking Walking Mesh Breathable Sneaker for CampingAnd are they paying a significant cost for this evolved resistance?Skechers Sport Men's Spider SneakerMen's Large Size Sandals Leather Beach shoes Casual Sandals and Slippers Men's shoes.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Men's Casual shoes Leather Sandals Summer Sneakers Men Slippers Flip Flops Casual shoes Beach OutdoorCHENXD shoes, Men's Genuine Leather Driving Loafers Penny Moccasins Soft Rubber Sole Boat shoes Sandals Outdoor Sports Strap Sandals Fashion Sandals Casual Summer Outdoor New Leather Non-Slip Dual-use Slippers (color Light Brown, Size 10 D(M) US)FH Leather shoes Men's Leather Dad shoes British Middle-Aged Casual Men's shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Black Jack Hand-Tooled Vamp Locust Cord BootAdidas NMD_CS2 PK Primeknit Womens Sneakers shoes-Navy-5.5factors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Williess shoes Men's Spring Men's shoes High to Help Men's White shoes (color White and Black, Size 44)Ino Summer Beach Flip Flops for Men Genuine Leather Outside Fashion Slippers Indoor Shower Waterproof Quick-Drying Anti-Slip Vapid Round Toe There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeHYZSX Rain Boots, Camouflage Rain Boots and Velvet shoes Executives shoes shoes Waterproof shoes Men's Multi-Size OptionalCHENXD shoes, Men's Fashion Comfortable Casual Classic Oxford Lace-up Work Leisure shoes.Adidas Women's Samoa W Originals Casual shoesIndian Wholesale 50 pc lot Bulk Mandala Ombre Hippie Assorted Bag Tribal Boho Shoulder & Handbag Ethnic Cotton Messenger Carry Bag With Shoulder Strap Tote Purse For Ladies by Craft Place CAD-40 At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, SnowSigner Natural Cow Leather Men's Travel Messenger Bags Handbag Briefcase Shoulder ToteCHENXD shoes, Men's British Style Rubber Sole Driving Loafer Wear Resistance Solid color Moccasinstherefore controlling for all the other “noise” out there in nature (StickSeek Luxury Genuine Leather Men's Tassels Formal Dress Loafers Alligator Pattern Round Toe Slip on Man Party shoes).GYYFC Men's Hollow Beach shoes Open Toe Embossing Leisure Flip Flops Lightweight Breathable Convenient Flip SandalsBAIDENG Breathable Outdoor Hiking shoes Camping Mountain Climbing Hiking Boots Men Waterproof Sport Fishing Boots Trekking Sneakers However,Indian Wholesale 50 pc lot Bulk Mandala Hand Bag Ethnic Clutches Purse Shoulder Assorted for Ladies by Panchal Creation-94Naturalizer Women's Blair Ankle Boot, Black, 11 Medium US I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Autumn winter Martin boots Men and high leather boots in England men's boots working boots tide boots-H Foot length=24.3CM(9.6Inch)